Glutaraldehyde Technological Frontier: Kupambana mu Ukadaulo Wotsutsana ndi Calcification

Pankhani ya ma implants a mtima ndi mitsempha yamagazi, glutaraldehyde yakhala ikugwiritsidwa ntchito kwa nthawi yayitali pochiza minofu ya nyama (monga ng'ombe) popanga ma valve a bioprosthetic. Komabe, magulu otsala a aldehyde opanda ma free aldehyde ochokera ku njira zachikhalidwe angayambitse calcification pambuyo pa implantation, zomwe zimapangitsa kuti zinthuzo zisamakhale zolimba kwa nthawi yayitali.

Pofuna kuthana ndi vutoli, kafukufuku waposachedwa wofalitsidwa mu Epulo 2025 adayambitsa njira yatsopano yochizira matenda oletsa calcium (dzina la mankhwala: Periborn), zomwe zapangitsa kuti pakhale kupita patsogolo kwakukulu.

1. Kukweza Kwambiri kwa Ukadaulo:

Yankho ili limabweretsa kusintha kwakukulu kwa njira yachikhalidwe yolumikizirana ndi glutaraldehyde:

Kulumikiza Zosungunulira Zachilengedwe:
Kulumikiza kwa Glutaraldehyde kumachitika mu organic solvent yokhala ndi 75% ethanol + 5% octanol. Njira imeneyi imathandiza kuchotsa bwino ma phospholipids a minofu panthawi yolumikizana - ma phospholipids ndi omwe amakhala malo oyambira a nucleation kuti calcium ilowe m'thupi.

Wothandizira Kudzaza Malo:

Pambuyo polumikizana, polyethylene glycol (PEG) imagwiritsidwa ntchito ngati chodzaza malo, kulowa m'mipata pakati pa ulusi wa collagen. Izi zonse zimateteza malo a nucleation a ma crystals a hydroxyapatite ndikuletsa kulowa kwa calcium ndi phospholipids kuchokera ku plasma ya wolandirayo.

Kusindikiza kwa Terminal:

Pomaliza, chithandizo cha glycine chimathetsa magulu otsala a aldehyde aulere, motero chimachotsa chinthu china chofunikira chomwe chimayambitsa calcium ndi cytotoxicity.

2. Zotsatira Zabwino Kwambiri Zachipatala:

Ukadaulo uwu wagwiritsidwa ntchito pa scaffold ya ng'ombe yotchedwa "Periborn." Kafukufuku wotsatira wachipatala wokhudza odwala 352 azaka zoposa 9 adawonetsa kuti palibe chithandizo chomwe chingachitike chifukwa cha mavuto okhudzana ndi mankhwala mpaka 95.4%, kutsimikizira kugwira ntchito kwa njira yatsopanoyi yolimbana ndi calcium komanso kulimba kwake kwapadera kwa nthawi yayitali.

Kufunika kwa Kupambana Uku:

Sikuti zimangothetsa vuto la nthawi yayitali pankhani ya ma valve a bioprosthetic, kukulitsa moyo wa mankhwala, komanso kuyika mphamvu zatsopano mu kugwiritsa ntchito glutaraldehyde mu zinthu zapamwamba kwambiri zamankhwala.