Glutaraldehyde Technological Frontier: Kupambana mu Anti-calcification Technology

Pankhani ya ma implants a mtima, glutaraldehyde yakhala ikugwiritsidwa ntchito pochiza minofu ya nyama (monga bovine pericardium) popanga ma valve a bioprosthetic. Komabe, magulu otsalira a aldehyde aulere kuchokera kumayendedwe azikhalidwe amatha kubweretsa kuwerengetsera pambuyo pa implantation, kusokoneza kulimba kwa zinthuzo.

Pothana ndi vutoli, kafukufuku waposachedwa yemwe adasindikizidwa mu Epulo 2025 adayambitsa njira yothanirana ndi calcification (dzina lazinthu: Periborn), ndikupita patsogolo modabwitsa.

1.Core Techological Upgrades:

Yankho ili limabweretsa kusintha kofunikira panjira yolumikizirana glutaraldehyde:

Organic Solvent Cross-Linking:
Glutaraldehyde cross-linking imapangidwa mu zosungunulira organic zopangidwa ndi 75% ethanol + 5% octanol. Njirayi imathandiza kuchotsa bwino minofu ya phospholipids panthawi yolumikizana-phospholipids kukhala malo oyambirira a nucleation for calcification.

Wothandizira Malo:

Pambuyo pa kugwirizanitsa, polyethylene glycol (PEG) imagwiritsidwa ntchito ngati malo odzaza malo, kulowetsa mipata pakati pa collagen fibers. Izi zonse zimateteza malo a nucleation a hydroxyapatite makhiristo ndipo amalepheretsa kulowa kwa calcium ndi phospholipids kuchokera ku plasma.

Kusindikiza Pomaliza:

Pomaliza, chithandizo cha glycine chimalepheretsa magulu otsalira, osinthika a aldehyde, potero amachotsa chinthu china chofunikira chomwe chimayambitsa calcification ndi cytotoxicity.

2.Zotsatira Zachipatala Zopambana:

Ukadaulo uwu wagwiritsidwa ntchito pa scaffold ya bovine pericardial yotchedwa "Periborn." Kafukufuku wotsatira zachipatala wokhudza odwala 352 pazaka za 9 adawonetsa ufulu wogwiritsanso ntchito chifukwa cha zinthu zokhudzana ndi mankhwala mpaka 95.4%, kutsimikizira kugwira ntchito kwa njira yatsopano yotsutsana ndi calcification komanso kukhazikika kwake kwa nthawi yaitali.

Kufunika kwa Kupambanaku:

Sikuti amangolimbana ndi vuto lomwe lakhalapo kwa nthawi yayitali pamagawo a bioprosthetic valves, kukulitsa moyo wazinthu, komanso kumawonjezera mphamvu zatsopano pakugwiritsa ntchito glutaraldehyde muzinthu zapamwamba kwambiri zamankhwala.